Table 3.

Correlation by groups between biochemical markers, body composition and viral parameters with bone mineral density of the lumbar spine in patients with chronic hepatitis B virus infection in use or not of antiretrovirals.

Variables	Lumbar spine
	Group 1 Without antiretrovirals	p value	Group 2 Tenofovir	p value	Group 3 Lamivudine/Entecavir	p value
Age (years)	0.075	0.709	− 0.214	0.292	0.189	0.344
Viral load (log)	− 0.044	0.019	0.156	0.434	0.062	0.758
Medication time (years)	–	–	− 0.162	0.428	− 0.259	0.190
Vitamin D (ng/ml)	0.092	0.645	0.368	0.064	0.002	0.988
BMI (kg/m2)	0.071	0.723	0.247	0.222	0.369	0.05*
Body fat (kg)	0.016	0.933	0.123	0.547	0.173	0.387
Lean Mass (kg)	0.0004	0.998	0.109	0.594	0.051	0.798
IGF-1 (ng/ml)	0.373	0.05*	0.155	0.448	0.010	0.957
DPD (nmol/mmol)	− 0.194	0.363	− 0.131	0.540	0.011	0.955
Osteocalcin (ng/ml)	− 0.108	0.613	− 0.526	0.008*	− 0.535	0.007*
Total Calcium (mg/dl)	− 0.231	0.244	0.261	0.188	0.253	0.002*
Phosphorus (mg/dl)	− 0.119	0.552	− 0.097	0.630	0.156	0.437
Magnesium (mg/dl)	− 0.026	0.05*	0.304	0.122	0.315	0.108
Urinary phosphorus (mg/l)	0.135	0.05*	0.266	0.179	0.002	0.988
PTH (pg/ml)	0.170	0.395	0.075	0.708	− 0.030	0.879
FGF-23 (pg/ml)	0.225	0.401	− 0.680	0.002*	0.205	0.427

Parameters with statistical differences are given in bold.

Pearson correlation, significance level p ≤ 0.05 indicated by *. DPD, deoxypyridinoline; PTH, parathormone; IGF-1, insulin-like growth factor-1; FGF-23, fibroblast growth factor 23; BMI, body mass index. FGF-23 n = 16–17 per group.