Table 3.

Rescue antiemetic medications by treatment groups utilized in the pivotal trials

n (%)	Placebo	Oliceridine demand dose			Morphine
		0.1 mg	0.35 mg	0.5 mg	1 mg
Hard tissue (orthopedic surgery-bunionectomy study)
N	79	76	79	79	76
Patients with at least one antiemetic	9 (11.4)	14 (18.4)	28 (35.4)	34 (43.0)	46 (60.5)
Ondansetron	7 (8.9)	14 (18.4)	28 (35.4)	34 (43.0)	46 (60.5)
Other antiemetics	2 (2.5)	0	1 (1.3)	0	0
Soft tissue (plastic surgery-abdominoplasty study)
N	83	77	79	80	82
Patients with at least one antiemetic	24 (28.9)	26 (33.8)	44 (55.7)	48 (60.0)	53 (64.6)
Ondansetron	24 (28.9)	25 (32.5)	44 (55.7)	48 (60.0)	53 (64.6)
Other antiemetics	2 (2.4)	2 (2.6)	0	1 (1.3)	2 (2.4)

Patients were counted once within each drug class and within each treatment group