Table 3.
Exposure to oliceridine
| ALL surgical patients | Age < 65 years | Age ≥ 65 years | BMI < 30 kg/m2 | BMI ≥ 30 kg/m2 | Age ≥ 65 years with BMI ≥ 30 kg/m2 | |
|---|---|---|---|---|---|---|
| N | 724 | 483 | 241 | 389 | 335 | 120 |
| Bolus, n (%) | 377 (52.0) | 302 (62.5) | 75 (31.1) | 217 (55.8) | 160 (47.8) | 33 (27.5) |
| PCA, n (%) | 347 (47.9) | 181 (37.5) | 166 (68.9) | 172 (44.2) | 175 (52.2) | 87 (72.5) |
| Cumulative dose of oliceridine (mg) | ||||||
| Mean ± SD | 31.2 ± 31.3 | 29.3 ± 32.3 | 34.8 ± 29.0 | 30.8 ± 31.7 | 31.6 ± 31.0 | 37.1 ± 28.1 |
| Median (min, max)/interquartile range |
21.0 (0.9, 22.3) 39.5 |
17.0 (0.9, 223.5) 35.0 |
28.0 (1, 154.5) 39.0 |
20.0 (0.9, 223.5) 41.0 |
23.0 (1, 165.0) 38.0 |
34.3 (1, 144.5) 42.5 |
| Duration of exposure (h) | ||||||
| Mean ± SD | 30.3 ± 26.8 | 26.3 ± 26.5 | 38.2 ± 25.8 | 30.7 ± 27.5 | 29.7 ± 26.0 | 39.8 ± 24.1 |
| Median (min, max)/interquartile range |
21.4 (0, 142.7) 41.6 |
17.4 (0, 142.7) 40.8 |
39.1 (0, 138.3) 41.2 |
20.8 (0, 138.3) 48.4 |
22.1 (0, 142.7) 37.5 |
39.6 (0, 130.8) 41.9 |