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. 2021 Apr 30;8:625763. doi: 10.3389/fmed.2021.625763

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Copyright © 2021 Pienkos, Gallego, Condon, Cruz-Utrilla, Ochoa, Nevado, Arias, Agarwal, Patel, Chakraborty, Lapunzina, Escribano, Tenorio-Castaño and de Jesús Pérez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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STRING analysis of TRAF2 and TNIP2 related to previously associated genes to PAH. (A) Protein network showing the possible interactions between all genes associated with PAH. This graph includes genes previously associated with PAH and candidate genes described in case reports/series. The strength of evidence for the relation between TRAF2 and CAV1 comes from published experimental/biochemical data and association in curated databases (see Methods). (B,C) Gene enrichment analysis, including biological processes (B) and interaction pathways (C) in which the STRING analysis genes are involved. Several genes are involved in the immune system process and participate in inflammation mediated by chemokine and cytokine signaling.