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. 2021 Apr 30;8:645378. doi: 10.3389/fcvm.2021.645378

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Copyright © 2021 Wu, Wu, Yang, Li, Peng, Wu, Yu and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CircHIPK3 sponges miR-93-5p as a ceRNA. (A) RNA-FISH was used to detect the subcellular localization of CircHIPK3. (B) Bioinformatic website predicted the binding relationship between CircHIPK3 and miR-93-5p. (C) Dual-luciferase reporter gene assay was used to verify the binding relationship between CircHIPK3 and miR-93-5p. (D) RIP assay was used to detect the relationship between CircHIPK3 and Ago2. (E) RNA pull-down test was used to verify the binding of CircHIPK3 and miR-93-5p. The value in the figures is the measurement data, which is expressed as mean ± standard deviation. The comparison between two groups was analyzed by independent-sample t-test. The comparison among multiple groups was analyzed by one-way ANOVA, followed by Tukey's multiple-comparisons test, *p < 0.05. The experiment was repeated three times.