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. 2021 Apr 30;12:651403. doi: 10.3389/fmicb.2021.651403

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Copyright © 2021 Shionoya, Yamasaki, Iwanami, Ito, Fukushi, Ohashi, Saso, Tanaka, Aoki, Kuramochi, Iwami, Takahashi, Suzuki, Muramatsu, Takeda, Wakita and Watashi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The anti-SARS-CoV-2 activity of MFQ and its derivatives. (A) Chemical structures of MFQ and its derivatives. (B) Extracellular SARS-CoV-2 RNA was quantified upon treatment with HCQ, MFQ and related compounds PRQ, Quinine and Quinidine at varying concentrations. Calculated inhibitory concentrations of 50, 90, and 99% maximum (IC₅₀, IC₉₀, and IC₉₉) for each compound are as indicated. (C) Cell viability was measured by MTT assay with the calculated 50% maximal cytotoxic concentration (CC₅₀).