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. 2021 May 13;4:571. doi: 10.1038/s42003-021-02089-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative view of H3K9me2 ChIP-seq data along chromosome 6 in iMEFs. Although H3K9me2 in the A compartments is decreased by UNC0642 treatment, low H3K9me2 signal is retained. Those retained H3K9me2 is further diminished in UNC0642-treated Setdb1 KO iMEFs. b Difference in G9a/GLP-independent H3K9me2 between mESCs and iMEFs. H3K9me2 domain size is larger in iMEFs than in mESCs. c A comparison between compartment score and H3K9me2 changes by UNC0642 treatment in iMEFs. Overall, H3K9me2 reduction in the A compartments is induced by the UNC0642 treatment. Each plot represents data from each 80-kb bin. Darker blue represents higher dot density. d Fractions of H3K9me2 domains in the A and B compartments in UNC0642-treated iMEFs. e A comparison between compartment score and H3K9me2 changes in UNC0642-treated Setdb1 KO iMEFs. In comparison with UNC0642-treated WT iMEFs (c), UNC0642-treated Setdb1 KO iMEFs showed further reduction of H3K9me2, especially in the A compartments. f The number and the length of H3K9me2 domains in WT and Setdb1 KO iMEFs treated with UNC0642. Both the number and the length of H3K9me2 domains in the A compartments are reduced in UNC0642-treated Setdb1 KO iMEFs. g H3K9me2 ChIP-qPCR analysis in regions showing in Supplementary Fig. 1o. H3K9me2 in the region 1 and 2 is completely lost in UNC0642-treated TKO iMEFs. Data are mean ± SEM; n = 3.