Table 2.
Hemodynamics, pulmonary mechanics, blood gas data, and preload indicators for each time interval.
| Variable | PEEP 5 | PEEP 10 | PEEP 15 | Pre Challenge | Post Challenge |
|---|---|---|---|---|---|
| HR (beats/min) | 118 (22) | 100 (31) | 116 (22) | 114 (21) | 109 (21)* |
| SAP (mmHg) | 136.9 (30.3) | 134.8 (29.4) | 123.2 (27.1)a,b | 125.2 (25.1) | 128.9 (21.5) |
| MAP (mmHg) | 86.7 (20.9) | 86.0 (19.9) | 79.2 (20.1)a,b | 81.5 (19.9) | 85.2 (16) |
| CI (L/min/.m2) | 3.88 (1.16) | 3.78 (1.07) | 3.66 (1.10)a | 3.59 (1.09) | 4.23 (1.31)* |
| SVI (mL/m2) | 33.3 (8.8) | 33.2 (8.2) | 31.7 (8.6)a | 31.6 (8.1) | 38.5 (8.6)* |
| SVRI (dynes/sec/cm5/m2) | 1555 (453) | 1592 (507) | 1479 (420)b | 1549 (392) | 1344 (535)* |
| Pplat (cmH2O) | 20.4 (4.3) | 24.32 (4.7)c | 31.39 (5.3)a,b | 30.36 (6.2) | 29.96 (6.1) |
| Pmean (cmH2O) | 10.39 (1.7) | 15.13 (2.4)c | 20.69 (2.1)a,b | 19.6 (3.1) | 19.7 (3.2) |
| Total PEEP (cm/H2O) | 6.15 (1.1) | 10.67 (0.8)c | 15.54 (0.8)a,b | 14.5 (1.5) | 14.7 (1.6) |
| Crs (mL/cmH2O) | 32.1 (14.8) | 35.3 (15.0) | 29.8 (14.1)b | 29.9 (11.9) | 30.5 (12.7) |
| Driving pressure (Pplat-total PEEP) (cm/H2O) | 14.25 (4.3) | 13.6 (4.9) | 15.86 (5.4)b | 15.9 (5.9) | 15.3 (5.9) |
| SVV (%) | 8.5 (5.4) | 9.3 (5.3) | 12.8 (7.2)a,b | 11.6 (6.8) | 7.8 (4.9)* |
| PPV (%) | 5.9 (3.8) | 6.2 (3.3) | 9.7 (5.0)a,b | 9.5 (5.4) | 5.7 (3.3)* |
| PPV/driving-P (%) | 0.46 (0.32) | 0.52 (0.4) | 0.68 (0.42)a,b | 0.63 (0.38) | 0.54 (0.69)* |
| PPV/Crs (%) | 0.22 (0.18) | 02.0 (0.12) | 0.39 (0.27)a,b | 0.38 (0.29) | 0.24 (0.19)* |
| PaO2 mmHg | 64.9 (17.3) | 85.6 (31.1)c | 89.2 (42.3)a | ||
| PaO2/FiO2 | 109.2 (54.5) | 138.7 (57)c | 143.8 (63.8)a | ||
| PaCO2 mmHg | 60.8 (19.9) | 60.9 (20.5) | 62.4 (20) | ||
| SaO2 (%) | 86.0 (8.9) | 92.5 (5.6)c | 92.7 (5.0)a |
Values are mean (SD).
HR heart rate, SAP systolic arterial pressure, MAP mean arterial pressure, CI cardiac index, SVI stroke volume index, SVRI systemic vascular resistance index, Pplat plateau pressure, Pmean mean airway pressure, Crs respiratory system compliance, PPV pulse pressure variation, SVV stroke volume variation.
aSignificantly different between PEEP 15 and PEEP 5.
bSignificantly different between PEEP 15 and PEEP 10.
cSignificantly different between PEEP 10 and PEEP 5.
*Significantly different between pre and post challenge.