Table 2.
Univariate analysis of factors associated with 28-day mortality.
| Variables | Deaths at day 28 (n = 67) | Survivals at day 28 (n = 364) | P-value | OR (95%CI) |
|---|---|---|---|---|
| Age, median (IQR) | 61.42 (53,74) | 59.92 (49,72) | 0.509 | 1.005 (0.990–1.021) |
| Male, n (%) | 42 (62.7) | 250 (68.7) | 0.336 | 1.305 (0.759–2.245) |
| Season, n (%) | ||||
| Spring | 25 (37.3) | 122 (33.5) | 0.547 | 1.181 (0.687–2.028) |
| Summer | 11 (16.4) | 92 (25.3) | 0.122 | 0.581 (0.292–1.156) |
| Autumn | 8 (11.9) | 67 (18.4) | 0.203 | 0.601 (0.274–1.317) |
| Winter | 23 (34.3) | 83 (22.8) | 0.046 | 1.770 (1.010–3.100) |
| Charlson Index, mean ± SD | 4.640 ± 1.747 | 4.150 ± 2.205 | 0.084 | 1.104 (0.987–1.235) |
| Comorbidities, n (%) | ||||
| Cardiovascular diseases | 28 (41.8) | 138 (37.9) | 0.549 | 1.176 (0.692–1.997) |
| Chronic renal insufficiency | 13 (19.4) | 48 (13.2) | 0.183 | 1.585 (0.805–3.120) |
| COPD | 19 (28.4) | 76 (20.9) | 0.177 | 1.500 (0.833–2.701) |
| Type II diabetes mellitus | 17 (25.4) | 84 (23.1) | 0.684 | 1.133 (0.621–2.069) |
| Solid tumor | 17 (25.4) | 89 (24.5) | 0.872 | 1.051 (0.577–1.914) |
| Hematologic malignancy | 1 (1.5) | 7 (1.9) | 0.811 | 0.773 (0.094–6.384) |
| Current or former smoker | 20 (29.9) | 140 (38.5) | 0.182 | 0.681 (0.387–1.197) |
| Admission source, n (%) | ||||
| Emergency department | 21 (31.3) | 89 (24.5) | 0.236 | 1.411 (0.799–2.491) |
| Operation theater | 14 (20.9) | 92 (25.3) | 0.445 | 0.781 (0.414–1.473) |
| Normal wards | 21 (31.3) | 105 (28.8) | 0.680 | 1.126 (0.641–1.979) |
| Other hospital | 11 (16.4) | 78 (21.4) | 0.353 | 0.720 (0.360–1.441) |
| Primary reason for ICU admission, n (%) | ||||
| Neurological | 7 (10.4) | 46 (12.6) | 0.617 | 0.807 (0.348–1.871) |
| Suspected sepsis | 14 (20.9) | 87 (23.9) | 0.594 | 0.841 (0.445–1.589) |
| Respiratory | 20 (29.9) | 109 (29.9) | 0.988 | 0.996 (0.563–1.759) |
| Cardiovascular(excluding stroke) | 16 (23.9) | 49 (13.5) | 0.031 | 2.017 (1.066–3.814) |
| Multiple trauma | 2 (3.0) | 23 (6.3) | 0.295 | 0.456 (0.105–1.982) |
| Burns | 1 (1.5) | 6 (1.6) | 0.926 | 0.904 (0.107–7.632) |
| Hepatobiliary and pancreatic | 2 (3.0) | 19 (5.2) | 0.441 | 0.559 (0.127–2.457) |
| Gastrointestinal | 2 (3.0) | 17 (4.7) | 0.540 | 0.628 (0.142–2.784) |
| Genitourinary | 3 (4.5) | 8 (2.2) | 0.287 | 2.086 (0.539–8.073) |
| XDR-AB colonization, n (%) | 12 (17.9) | 65 (17.9) | 0.992 | 1.004 (0.509–1.980) |
| XDR-AB infection, n (%) | 7 (10.4) | 23 (6.3) | 0.227 | 1.730 (0.711–4.210) |
| Acuity score on admission | ||||
| APACHE II score, mean ± SD | 22.475 ± 6.647 | 13.953 ± 8.554 | <0.001 | 1.114 (1.078–1.150) |
| Intensity of care, n (%) | ||||
| Invasive ventilation for more than 5 days | 39 (58.2) | 170 (46.7) | 0.085 | 1.589 (0.938–2.693) |
| Renal replacement therapy | 16 (23.9) | 55 (15.1) | 0.078 | 1.763 (0.938–3.311) |
| Vasopressor treatment for more than 3 days | 67 (100) | 33 (9.1) | 0.992 | 3.279 (0.978–7.923) |
Data are number (%), median (IQR) or mean ± SD. OR, odds ratio; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; XDR-AB, extensively drug-resistant Acinetobacter baumannii; APACHE, Acute Physiology and Chronic Health Evaluation; IQR, interquartile range; SD, standard deviation.