Table 4.
Univariate Analysis of Factors Associated with mortality in 6 months.
| Variables | Deaths at 6 months (n = 207) | Survival at 6 months (n = 224) | P-value | HR (95%CI) |
|---|---|---|---|---|
| Age, median (IQR) | 59.92 (49,72) | 55.4 (46,67.75) | <0.001 | 1.026 (1.017–1.035) |
| Male, n (%) | 138 (66.7) | 154 (68.8) | 0.464 | 1.114 (0.834–1.487) |
| Season, n (%) | ||||
| Spring | 70 (33.8) | 77 (34.4) | 0.879 | 0.978 (0.733–1.304) |
| Summer | 45 (21.7) | 58 (25.9) | 0.226 | 0.815 (0.586–1.134) |
| Autumn | 36 (17.4) | 39 (17.4) | 0.900 | 1.023 (0.714–1.466) |
| Winter | 56 (27.1) | 50 (222.3) | 0.190 | 1.227 (0.903–1.668) |
| Charlson Index, mean ± SD | 4.630 ± 2.063 | 3.850 ± 2.158 | <0.001 | 1.114 (1.056–1.175) |
| Comorbidities, n (%) | ||||
| Cardiovascular diseases | 103 (49.8) | 63 (28.1) | <0.001 | 1.859 (1.414–2.443) |
| Chronic renal insufficiency | 46 (22.2) | 15 (6.7) | <0.001 | 2.231 (1.605–3.101) |
| COPD | 63 (30.4) | 32 (14.3) | <0.001 | 1.897 (1.409–2.554) |
| Type II diabetes mellitus | 56 (27.1) | 45 (20.1) | 0.093 | 1.301 (0.957–1.769) |
| Solid tumor | 41 (19.8) | 65 (29.0) | 0.064 | 0.724 (0.514–1.019) |
| Hematologic malignancy | 5 (2.4) | 3 (1.3) | 0.500 | 1.357 (0.559–3.296) |
| Current or former smoker | 73 (35.3) | 87 (38.8) | 0.322 | 0.866 (0.651–1.152) |
| Admission source, n (%) | ||||
| Emergency department | 56 (27.1) | 54 (24.1) | 0.503 | 1.111 (0.817–1.509) |
| Operation theater | 51 (24.6) | 55 (24.6) | 0.981 | 1.004 (0.732–1.377) |
| Normal wards | 58 (28.0) | 68 (30.4) | 0.719 | 0.946 (0.698–1.281) |
| Other hospital | 42 (20.3) | 47 (21.0) | 0.737 | 0.944 (0.672–1.324) |
| Primary reason for ICU admission, n (%) | ||||
| Neurological | 22 (10.6) | 31 (13.8) | 0.298 | 0.791 (0.508–1.230) |
| Suspected sepsis | 53 (25.6) | 48 (21.4) | 0.363 | 1.156 (0.846–1.579) |
| Respiratory | 63 (30.4) | 66 (29.5) | 0.871 | 1.025 (0.762–1.378) |
| Cardiovascular(excluding stroke) | 40 (19.3) | 25 (11.2) | 0.005 | 1.640 (1.161–2.318) |
| Multiple trauma | 9 (4.3) | 16 (7.1) | 0.217 | 0.656 (0.337–1.281) |
| Burns | 2 (1.0) | 5 (2.2) | 0.341 | 0.508 (0.126–2.047) |
| Hepatobiliary and pancreatic | 4 (1.9) | 17 (7.6) | 0.024 | 0.321 (0.119–0.864) |
| Gastrointestinal | 7 (3.4) | 12 (5.4) | 0.362 | 0.704 (0.332–1.497) |
| Genitourinary | 6 (2.9) | 5 (2.2) | 0.770 | 1.129 (0.501–2.542) |
| XDR-AB colonization, n (%) | 53 (25.6) | 24 (10.7) | <0.001 | 1.898 (1.387–2.598) |
| XDR-AB infection, n (%) | 20 (9.7) | 10 (4.5) | 0.034 | 1.649 (1.039-2.616) |
| Acuity score on admission | ||||
| APACHE II score, mean ± SD | 21.936 ± 7.406 | 9.125 ± 4.556 | <0.001 | 1.107 (1.094–1.121) |
| Intensity of care, n (%) | ||||
| Invasive ventilation for more than 5 days | 118 (57.0) | 91 (40.6) | <0.001 | 1.641 (1.246–2.161) |
| Renal replacement therapy | 44 (21.3) | 27 (12.1) | 0.005 | 1.616 (1.158–2.255) |
| Vasopressor treatment for more than 3 days | 91 (44.0) | 9 (4.0) | <0.001 | 7.849 (5.913–10.419) |
Data are number (%), median (IQR) or mean ± SD. HR, hazard ratio; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; XDR-AB, extensively drug-resistant Acinetobacter baumannii; APACHE, Acute Physiology and Chronic Health Evaluation; IQR, interquartile range; SD, standard deviation.