Fig. 5.

Effect of dedicator of cytokinesis 2 (Dock2) on the phagocytic and bactericidal function of macrophages. Bone marrow‐derived macrophages (BMDM) (10⁶) were infected with 10 multiplicity of infection (MOI) Citrobacter rodentium or Salmonella typhmurium. Wild‐type (WT) and Dock2^−/− BMDM were lysed at 2 and 20 h after infection, and the numbers of intracellular C. rodentium and S. typhmurium were determined using the colony‐forming unit (CFU) method (a,b). Data were representative of two independent experiments [mean ± standard error of the mean (s.e.m.)]. Data were analyzed by two‐tailed t‐test at each time‐point. **P < 0·01.