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Paw volume, gait score and the damage of synovial tissue were increased in monosodium urate (MSU)‐induced gout arthritis (GA) rats after injection of MSU or normal saline for 24 h. (a) Pictures of rat paws are shown; (b) volume of rat paws was measured using a PBC7140 plethysmometer at 0, 6, 12 and 24 h; (c) gait score was documented by three observers; (d) pathological damage of rat joint was observed by hematoxylin and eosin staining (*** P < 0·001 versus sham).
