Fig. 2.

Inflammation‐related factors were abnormally expressed in monosodium urate (MSU)‐induced gout arthritis (GA) rats. After injection of MSU or normal saline for 24 h. (a–c) Secretion levels of interleukin (IL)‐1β, tumor necrosis factor (TNF)‐α and articular elastase in the serum of the rats were detected by enzyme‐linked immunosorbent assay (ELISA); (d) expression levels of IL‐1β, NLRP3 and cleaved caspase‐1 in the joint tissues of the rats were detected by immunohistochemistry analysis (^*** P < 0·001 versus sham).