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. 2021 Mar 9;204(3):396–410. doi: 10.1111/cei.13587

Fig. 8.

Fig. 8

NLR family pyrin domain containing 3 (NLRP3) over‐expression reversed the effect of miR‐223‐3p mimic on the expressions of apoptosis‐associated speck‐like protein, cleaved caspase‐1, cleaved N‐terminal gasdermin D (GSDMD) and interleukin (IL‐1β) in monosodium urate (MSU)‐induced FLSs. (a–e) The expressions of apoptosis‐associated speck‐like protein (ASC), cleaved caspase‐1, cleaved N‐terminal GSDMD and IL‐1β in the rat fibroblast‐like synoviocytes after treatment with MSU and transfection with miR‐223‐3p mimic or NLRP3 was detected by Western blot; β‐actin was used as an internal control; (f,g) the expressions of ASC and IL‐1β in the rat FLSs after treatment with MSU and transfection with miR‐223‐3p mimic or NLRP3 was detected by reverse transcription–quantitative polymerase chain reaction (RT–qPCR). (** P < 0.01, *** P < 0.001, versus MSU; ## P < 0.01, versus MSU+M+NC). M: miR‐223‐3p mimic; NC: negative control.