Table 2.
Bacterial operational taxonomic units (OTUs) correlated with composite follicular T helper (Tfh) profile genes (SUM; Figs 5 and 6) in adult and young healthy, diseased, and resolution samples. The asterisk (*) identifies bacterial clusters strongly correlated with an array of the Tfh genes but not directly correlated with the composite profile. Mixed denotes significant positive and negative correlations with Tfh genes
| Sample | Health | Disease | Resolution |
|---|---|---|---|
| Adult | |||
| Positive | Prevotella unclassified | Treponema maltophilum 664 | Streptococcus sp. 058 |
| Aggregatibacter unclassified | Prevotella enoeca 600 | Treponema socranskii 769 | |
| Moraxella catarrhalis 833 | Fretibacterium sp. 361 | Prevotella sp. 317 | |
| Selenomonas_unclassified | Porphyromonas gingivalis 619 | Selenomonas_unclassified | |
| Porphyromonas sp. 279 | Fretibacterium fastidiosum 363 | Catonella morbi 165 | |
| Haemophilus sp. 035 | Porphyromonas endodontalis 273 | Pasteurellaceae_unclassified | |
| Leptotrichia_unclassified | |||
| Positive* | Fretibacterium sp. 361 | Selenomonas sputigena 151 | |
| Fretibacterium fastidiosum 363 | Veillonellaceae_[G‐1] sp. 155 | ||
| Treponema sp. 246 | Fusobacterium sp. 203 | ||
| A. actinomycetemcomitans 531 | Prevotella denticola 291 | ||
| Peptostreptococcaceae_[XIII]_ | Leptotrichia_unclassified | ||
| unclassified | Veillonella unclassified | ||
| Prevotella enoeca 600 | Prevotella sp. 311 | ||
| Prevotella sp. 317 | |||
| Fretibacterium unclassified | |||
| Desulfobulbus sp. 041 | |||
| Mixed* | Porphyromonas sp. 279 | ||
| Porphyromonas gingivalis 619 | |||
| Gemella morbillorum 046 | |||
| Fusobacterium unclassified | |||
| Capnocytophaga_unclassified | |||
| Fretibacterium unclassified | |||
| Mixed* | Prevotella sp. 311 | ||
| Prevotella denticola 291 | |||
| Veillonella parvula 161 | |||
| Megasphaera micronuciformis 122 | |||
| Streptococcus_unclassified | |||
| Veillonella unclassified | |||
| Haemophilus sp. 035 | |||
| Negative | Selenomonas sputigena 151 | Gemella morbillorum 046 | Prevotella sp. 526 |
| Leptotrichia sp. 223 | Porphyromonas sp. 279 | Fusobacterium sp. 203 | |
| Bacteria_unclassified | Bacteroidetes_unclassified | Eubacterium infirmum 105 | |
| Pyramidobacter piscolens 357 | Moraxella catarrhalis 833 | Moraxella catarrhalis 833 | |
| Veillonellaceae_[G‐1] sp. 155 | Haemophilus sp. 035 | Treponema unclassified | |
| Streptococcus sp. 058 | A. actinomycetemcomitans 531 | ||
| Treponema denticola 584 | |||
| Young | |||
| Positive | Haemophilus sp. 035 | Prevotella sp. 317 | Prevotella enoeca 600 |
| Capnocytophaga_unclassified | A. actinomycetemcomitans 531 | Selenomonas_unclassified | |
| Moraxella catarrhalis 833 | Veillonella parvula 161 | Catonella morbi 165 | |
| Prevotella_unclassified | Moraxella catarrhalis 833 | SR1_[G‐1]sp. 345 | |
| Eubacterium_[XI][G‐1]infirmum 105 | Prevotella sp. 317 | ||
| Filifactor alocis 539 | Moraxella catarrhalis 833 | ||
| Positive* | Treponema sp. 246 | ||
| Fretibacterium_unclassified | |||
| Leptotrichia_unclassified | |||
| Porphyromonas endodontalis 273 | |||
| Positive* | Peptostreptococcaceae_[XIII]_ | ||
| unclassified | |||
| Bacteroidetes_unclassified | |||
| Treponema_unclassified | |||
| Pyramidobacter piscolens 357 | |||
| Mixed* | Veillonellaceae_[G‐1]_unclassified | ||
| Prevotella sp. 820 | |||
| Fretibacterium sp. 361 | |||
| Prevotella sp. 526 | |||
| Porphyromonas gingivalis 619 | |||
| Eubacterium_[XI][G‐1]infirmum 105 | |||
| Leptotrichia sp. 223 | |||
| Chloroflexi_[G‐1]sp. 439 | |||
| Fretibacterium_unclassified | |||
| Fretibacterium fastidiosum 363 | |||
| Fusobacterium_unclassified | |||
| Filifactor alocis 539 | |||
| Prevotella sp. 304 | |||
| Prevotella_unclassified | |||
| Negative* | Prevotella sp. 526 | Eubacterium_[XI][G‐1]infirmum 105 | Peptostreptococcaceae_[XIII]_ |
| Bacteria_unclassified | Prevotella sp. 313 | unclassified | |
| Chloroflexi_[G‐1]sp. 439 | Prevotella sp. 820 | Treponema denticola 584 | |
| Selenomonas_unclassified | Veillonellaceae_[G‐1]_unclassified | Treponema maltophilum 664 | |
| Veillonellaceae_[G‐1]sp. 155 | Prevotella intermedia 643 | Treponema_unclassified | |
| Prevotella sp. 820 | A. actinomycetemcomitans 531 | ||
| Prevotella sp. 317 | |||
| Veillonella parvula 161 | |||
| Pyramidobacter piscolens 357 | |||
| Prevotella sp. 304 | |||
| Negative | Bacteroidetes_unclassified | Catonella morbi 165 | Streptococcus parasanguinis_II 411 |
| Porphyromonas endodontalis 273 | Bacteria_unclassified | Prevotella fusca 782 | |
| Leptotrichia_unclassified | Treponema maltophilum 664 | Pasteurellaceae_unclassified | |
| Fusobacterium sp. 203 | Fretibacterium sp. 361 | Gemella morbillorum 046 | |
| Selenomonas sputigena 151 | Streptococcus parasanguinis_II 411 | ||
| Fretibacterium fastidiosum 363 | |||
| Selenomonas_unclassified | |||
| Fusobacterium_unclassified | |||
| Filifactor alocis 539 |