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. 2021 Apr 30;12:656846. doi: 10.3389/fimmu.2021.656846

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Copyright © 2021 van der List, Litjens, Klepper and Betjes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TIGIT-expressing donor-reactive CD137+ CD4+ T cells significantly decline within first 6 months following transplantation. The two panels on the left (A, B) represent PBMCs stimulated with donor-antigen while those on the left (C, D) represent PBMCs stimulated with non-donor (third party) antigen. In the top panels the percentage of CD4+ T cells co-expressing CD137 and TIGIT is illustrated prior to transplantation (timepoint 0) and at 6 and at 12 months following transplantation for 6 kidney transplant recipients per timepoint. In the bottom panels the MFI of TIGIT-expressing cells within the CD4+CD137+ T cell population is depicted.