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. 2021 Apr 30;12:656846. doi: 10.3389/fimmu.2021.656846

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Copyright © 2021 van der List, Litjens, Klepper and Betjes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4+CD137+TIGIT+ T cells have a predominantly central and effector memory T cell phenotype and express both CD27 and CD28. (A) A representative sample of the 3 healthy individuals stimulated with alloantigen illustrates how CD4+CD137+ T cells were gated and split into a TIGIT positive and TIGIT negative fraction. (B) Expression of CD45RA and CCR7 was compared for both CD4+CD137+ T cells expressing TIGIT (left) and negative for TIGIT (right) of 3 healthy individuals. The percentage of gated CD4+CD137+TIGIT+ and gated CD4+CD137+TIGIT- cells are indicated within each quadrant. (C) Naïve, central memory (CM), effector memory (EM) or terminally differentiated effector memory (EMRA) cells are depicted as proportion of CD4+CD137+ T cells either positive (closed symbols) or negative (open symbols) for TIGIT of 3 healthy individuals. (D) Expression of CD27 and CD28 was illustrated for both CD4+CD137+ T cells expressing TIGIT (left) and negative for TIGIT (right). The percentage of gated CD4+CD137+TIGIT+ and gated CD4+CD137+TIGIT- cells are indicated within each quadrant. (E) The proportion of CD4+CD137+ T cells either positive (closed symbols) or negative (open symbols) for TIGIT and expressing CD28 and CD27 are depicted.