FIGURE 4.

Fold-change of caspase-3 activity in MS13-treated (A) U-87 MG and (B) SH-SY5Y cells. The caspase-3 activity was measured relative to control (0.2% DMSO) treatment at 24, 48, and 72 h. All experiments were performed in triplicates and results were compared between three biological replicates. Statistical analysis was performed using ANOVA, comparing the caspase-3 activity upon treatment with each MS13 dose at each time point to the respective untreated control sample. Indication of asterisks: *p < 0.05; **p < 0.01.