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. 2021 May 13;12(5):483. doi: 10.1038/s41419-021-03765-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Representative Micro-CT images for medial and coronal planes of femoral condyle and tibial plateau in OA mice. B–D The effects of KGN on subchondral bone parameters including B bone volume ratio (BV/TV, %), C trabecular separation (Tb.Sp., mm), and D trabecular thickness (Tb.Th., mm). Values represent mean ± S.E.M of four replicas. (*p < 0.05 and **p < 0.01; between the indicated groups and ^#p < 0.05 or ^##p < 0^.01 versus the CTRL group).