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. 2021 May 13;12:2773. doi: 10.1038/s41467-021-22674-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Relative quantification of the CD3⁺ T cells in the PB, n = 5 biologically independent animals. b Representative flow cytometry analysis of CD4⁺ T cells, CD8⁺ T cells gating on CD3⁺ T cells. Relative quantification of the c CD4⁺ T cells and d CD8⁺ T cells, n = 5 biologically independent animals. e Representative immunofluorescence images of metastatic tumour in the lung showing CD4⁺ T cells (green) and CD8⁺ T cells (red) after treatment, scale bar: 100 µm. Representative flow cytometry analysis of f IFN-γ⁺CD8⁺ T cells and g Ki-67⁺CD8⁺ T cells gating on CD3⁺ T cells, n = 5 biologically independent animals. h Cytokine levels in the serum of mice, n = 5 biologically independent animals. G1, PBS; G2, aPDL1; G3, Vadimezan; G4, P@aPDL1; G5, P@aPDL1 + Vadimezan; G6, P@IgG + Vadimezan. Data are presented as mean ± SD, statistical significance was analysed via ANOVA (one-way, Tukey post-hoc test). P-value: **P < 0.01, ***P < 0.001. a G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001. c G1 vs. G5: P < 0.0001, G2 vs. G5: P = 0.0007, G3 vs. G5: P = 0.0018, G4 vs. G5: P = 0.0005, G6 vs. G5: P < 0.0001. d G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001. f G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001. g G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001. h TNF-α: G1 vs. G5: P < 0.0001, G2 vs. G5: P = 0.0009, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001; IFN-γ: G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001; IL-2: G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P = 0.0007, G6 vs. G5: P < 0.0001; IL-6: G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001; IL-12: G1 vs. G5: P < 0.0001, G2 vs. G5: P < 0.0001, G3 vs. G5: P < 0.0001, G4 vs. G5: P < 0.0001, G6 vs. G5: P < 0.0001.