Fig. 2.
Mean peak visual analog ratings (n = 8; ±1 SEM) are displayed as a function of tradipitant and oxycodone dose. These data were collected during the sample sessions. Significant main effects of oxycodone dose were found for Emax for drug liking (upper left: F(2,14) = 24.5, p < 0.0001), good effects (upper right: F(2,14) = 30.8, p < 0.0001), and any drug effect (lower left; F(2,14) = 35.6 p < 0.0001). There was a main effect of tradipitant on ratings for desire for opiates (Emin) (lower right; F(1,7) = 5.7, p = 0.048), but no significant post hoc differences. Asterisks (*) indicate a significant difference from the placebo within tradipitant condition (e.g., 0 mg vs. 15 within the placebo tradipitant condition) (Tukey post hoc, p < 0.05)