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Mean (n = 8; ±1SEM) peak ratings are displayed as a function of tradipitant and oxycodone dose with data collected during the sample sessions. Significant main effects of oxycodone were found for Emin pupil diameter (F(2,14) = 93.5, p < 0.0001), Emin respiratory rate (F(2,14) = 4.4, p = 0.03), and Emax end tidal CO2 (F(2,14) = 20.5 p < 0.001). Asterisks (*) indicate a significant difference from the placebo within tradipitant condition (Tukey post hoc, p < 0.05)
