Fig. 5.

Mean values (n = 8; ±1 SEM) are shown for behavioral (threshold and tolerance) and subjective cold pressor outcomes as a function of tradipitant and oxycodone dose. Oxycodone dose is displayed on the x-axis; tradipitant data (open symbols denote 0 mg/bid; black symbols denote 85 mg/bid) are shown as line functions after initiation (circles) and steady state (squares). There was a main effect of oxycodone for all outcomes (cold pressor threshold F_{(4, 28)} = 12.9, p < 0.0001; cold pressor tolerance F_{(4, 28)} = 18.5, p < 0.0001; painful F_{(4, 28)} = 13.2, p < 0.0001; intense F_{(4, 28)} = 14.9, p < 0.0001)