Table 2.
Data are shown for outcomes from the sample sessions only for which significant effects of oxycodone were found (means (SEM)); data depicted elsewhere graphically are not included
| Oxycodone (mg IN) | |||||||
|---|---|---|---|---|---|---|---|
| 0 | 15 | 30 | |||||
| Tradipitant (mg p.o./bid) | |||||||
| F (2,14) | 0 | 85 | 0 | 85 | 0 | 85 | |
| Maximum Peak Values | |||||||
| Subjective Outcomes | |||||||
| VAS High | 34.82 | 3.38 (2.10) | 0.00 (0.00) | 22.00 (6.89) | 12.25 (3.12) | 39.75 (7.09) | 36.88 (5.82) |
| Street Value ($) | 41.31 | 0.86 (0.64) | 0.00 (0.00) | 14.75 (3.05) | 13.88 (2.57) | 25.44 (4.86) | 26.13 (5.70) |
| Adjective Agonist Scale | 38.71 | 6.75 (1.53) | 7.13 (1.39) | 12.00 (1.46) | 11.75 (1.97) | 17.75 (1.90) | 19.25 (3.20) |
| Observer-rated Outcomes | |||||||
| Adjective Agonist Scale | 17.23 | 4.63 (0.46) | 4.75 (0.53) | 7.63 (0.73) | 6.88 (0.77) | 9.63 (0.96) | 11.38 (2.01) |
| Skin Itchy | 21.63 | 0.00 (0.00) | 0.00 (0.00) | 0.63 (0.26) | 0.50 (0.27) | 1.25 (0.25) | 1.63 (0.32) |
| Nodding | 4.22 | 0.00 (0.00) | 0.00 (0.00) | 0.38 (0.18) | 0.00 (0.27) | 0.38 (0.38) | 0.88 (0.40) |
| Relaxed | 9.02 | 1.00 (0.00) | 1.00 (0.00) | 1.63 (0.26) | 0.00 (0.00) | 1.88 (0.23) | 2.00 (0.27) |
| Coasting | 7.12 | 0.25 (0.25) | 0.00 (0.00) | 0.25 (0.16) | 0.00 (0.00) | 0.63 (0.38) | 1.00 (0.33) |
| Talkative | 12.66 | 0.75 (0.25) | 0.63 (0.26) | 1.50 (0.19) | 1.50 (0.19) | 1.63 (0.26) | 1.88 (0.35) |
| Heavy/Sluggish | 6.16 | 0.00 (0.00) | 0.25 (0.16) | 0.75 (0.37) | 0.00 (0.00) | 0.75 (0.41) | 1.00 (0.33) |
| Sleepy | 7.49 | 0.38 (0.18) | 0.88 (0.30) | 1.00 (0.38) | 0.50 (0.27) | 1.38 (0.46) | 1.50 (0.42) |
| Good Mood | 8.93 | 0.88 (0.13) | 1.00 (0.00) | 1.25 (0.16) | 1.63 (0.18) | 1.63 (0.18) | 1.75 (0.31) |
| Energetic | 5.63 | 0.25 (0.16) | 0.00 (0.00) | 0.75 (0.16) | 0.50 (0.19) | 0.75 (0.25) | 0.88 (0.35) |
| Physiological Outcomes | |||||||
| Systolic BP (peak) | 4.07 | 115.95 (3.25) | 117.06 (1.85) | 120.25 (4.37) | 120.89 (2.22) | 122.19 (3.15) | 121.84 (3.52) |
| Heart Rate (trough) | 6.09 | 61.80 (3.13) | 60.79 (3.52) | 57.60 (2.85) | 58.88 (2.57) | 56.93 (3.06) | 57.14 (1.98) |
| Mean Arterial BP (peak) | 3.85 | 86.36 (2.06) | 87.75 (2.05) | 87.75 (2.05) | 87.45 (1.50) | 88.97 (1.75) | 88.94 (2.18) |
| Oxygen Saturation (trough) | 26.76 | 97.03 (0.26) | 97.55 (0.24) | 96.19 (0.31) | 96.38 (0.19) | 95.51 (0.42) | 95.74 (0.37) |
Bolded values indicate a significant difference between placebo and active oxycodone within tradipitant dose condition