Table 3.
Baseline characteristics in the training and the validation cohorts of N3-NSCLC patients.
| Characteristic |
Training cohort
(N = 12,219) |
Validation cohort
(N = 12,528) |
P-value | |
|---|---|---|---|---|
| Age | <67, median | 6,059 (49.6) | 6,183 (49.4) | 0.723 |
| ≥67 | 6,160 (50.4) | 6,345 (50.6) | ||
| Race | White | 9,396 (76.9) | 9,614 (76.7) | 0.901 |
| Black | 1,665 (13.6) | 1,732 (13.8) | ||
| Others | 1,158 (9.5) | 1,182 (9.4) | ||
| Sex | Male | 6,905 (56.5) | 7,034 (56.1) | 0.572 |
| Female | 5,314 (43.5) | 5,494 (43.9) | ||
| Laterality | Right | 6,519 (53.4) | 6,626 (52.9) | 0.027 |
| Left | 4,978 (40.7) | 5,246 (41.9) | ||
| Unknown | 722 (5.9) | 656 (5.2) | ||
| Primary site | Upper lobe | 6,449 (52.8) | 6,592 (52.6) | 0.429 |
| Middle lobe | 494 (4.0) | 497 (4.0) | ||
| Lower lobe | 2,833 (23.2) | 3,021 (24.1) | ||
| Main bronchus | 610 (5.0) | 627 (5.0) | ||
| Overlapping lesion | 123 (1.0) | 130 (1.0) | ||
| Unknown | 1,710 (14.0) | 1,661 (13.3) | ||
| Stage | IIIB | 3,370 (27.6) | 3,392 (27.1) | 0.381 |
| IV | 8,849 (72.4) | 9,136 (72.9) | ||
| T stage | T1 | 1,388 (11.4) | 1,379 (11.0) | 0.001 |
| T2 | 2,783 (22.8) | 2,917 (23.3) | ||
| T3 | 2,847 (23.3) | 3,083 (24.6) | ||
| T4 | 4,036 (33.0) | 4,121 (32.9) | ||
| TX | 1,165 (9.5) | 1,028 (8.2) | ||
| Bone metastasis | No | 8,492 (69.5) | 8,584 (68.5) | 0.072 |
| Yes | 3,428 (28.1) | 3,665 (29.3) | ||
| Unknown | 299 (2.4) | 279 (2.2) | ||
| Brain metastasis | No | 9,641 (78.9) | 9,920 (79.2) | 0.138 |
| Yes | 2,250 (18.4) | 2,321 (18.5) | ||
| Unknown | 328 (2.7) | 287 (2.3) | ||
| Liver metastasis | No | 10,344 (84.7) | 10,610 (84.7) | 0.055 |
| Yes | 1,536 (12.6) | 1,627 (13.0) | ||
| Unknown | 339 (2.8) | 291 (2.3) | ||
| Lung metastasis | No | 8,446 (69.1) | 8,626 (68.9) | 0.005 |
| Yes | 3342 (27.4) | 3,544 (28.3) | ||
| Unknown | 431 (3.5) | 358 (2.9) | ||
| Histology | ADC | 6,601 (54.0) | 7,073 (56.5) | <0.001 |
| SCC | 2,807 (23.0) | 2,781 (22.2) | ||
| Other NSCLC | 2,811 (23.0) | 2,674 (21.3) | ||
| Grade | I | 202 (1.7) | 217 (1.7) | 0.217 |
| II | 1,194 (9.8) | 1,274 (10.2) | ||
| III | 3,233 (26.5) | 3,156 (25.2) | ||
| IV | 173 (1.4) | 174 (1.4) | ||
| Unknown | 7,417 (60.7) | 7,707 (61.5) | ||
| Surgery | Yes | 11,983 (98.1) | 12,259 (97.9) | 0.248 |
| No | 236 (1.9) | 269 (2.1) | ||
| Chemotherapy | Yes | 3,924 (32.1) | 3,958 (31.6) | 0.387 |
| No/unknown | 8,295 (67.9) | 8,570 (68.4) | ||
| Radiotherapy | Yes | 5,903 (48.3) | 6,073 (48.5) | 0.804 |
| No/unknown | 6,316 (51.7) | 6,455 (51.5) |
NSCLC, non-small cell lung cancer; ADC, adenocarcinoma; SCC, squamous cell carcinoma.