Table 3.
Association of neutrophil-to-lymphocyte ratio (NLR) with clinical and histologic disease severity in 91 dogs with chronic enteropathy.
| Parameter | NLR, median | p value |
|---|---|---|
| Clinical disease severity (CCECAI score; n = 65) | ||
| Mild clinical disease (CCECAI score: 4–5) | 3.7 (2.2–7.0) | 0.026 |
| Moderate clinical disease (CCECAI score: 6–8) | 3.7 (2.3–8.3) | |
| Severe clinical disease (CCECAI score: 9–11) | 4.9 (4.6–13.1) | |
| Very severe clinical disease (CCECAI score: ≥12) | 12.7 (5.7–33.8) | |
| Histologic lesion severity | ||
| Mild histologic lesions (grade 1) | 4.6 (1.9–9.6) | 0.265 |
| Moderate histologic lesions (grade 2) | 6.9 (3.9–9.4) | |
| Severe histologic lesions (grade 3) | 5.3 (3.3–17.3) | |
| Presence and severity of lacteal dilation and/or crypt abscesses | ||
| Mild histologic lesions (grade 1) | 5.2 (2.1–10.6) | 0.285 |
| Moderate histologic lesions (grade 2) | 5.8 (3.1–9.4) | |
| Severe histologic lesions (grade 3) | 6.9 (4.0–11.6) | |
| Prognostic clinicopathologic variables | ||
| Normoalbuminemia | 3.7 (2.6–8.3) | 0.0007 |
| Hypoalbuminemia | 7.1 (4.9–15.7) | |
| Serum albumin concentration >20 g/L | 4.5 (2.7–7.7) | <0.0001 |
| Serum albumin concentration 15–20 g/L | 8.0 (6.1–17.0) | |
| Serum albumin concentration 12–14.9 g/L | 9.2 (6.5–11.3) | |
| Serum albumin concentration <12 g/L | 22.8 (18.4–38.2) | |
| Normocobalaminemia* | 5.7 (2.9–10.5) | 0.312 |
| Hypocobalaminemia† | 5.9 (3.7–13.4) | |
CCECAI = canine chronic enteropathy clinical disease activity index2.
Numbers in parentheses are interquartile ranges.
*
Defined as a serum cobalamin concentration ≥300 ng/L.
†
Defined as a serum cobalamin concentration <221 pmol/L (<300 ng/L).