Fig. 1.

Proteomic analysis reveals enrichment of FXII and pathways involved in platelet, complement and neutrophil activation in lung tissue from COVID-19 patients. (a) Heatmap of differentially regulated proteins in the lung tissue of patients with COVID-19 and COVID-19-independent lung pathologies (CTRL) (n = 3 each). (b) Selected Gene Ontology (GO) terms of increased proteins in COVID-19 lungs highlighting pathways involved in platelet (magenta), complement (green) and neutrophil activation (blue) and angiogenesis (red). (c) Protein association network analysis (https://string-db.org) of increased proteins in COVID-19 lungs. (d) Representative immunofluorescence of lung vibratome sections using antibodies against Collagen I (green) and fibrin (magenta) shows large fibrin depositions lining the alveolar space of FXII-increased COVID-19 lungs (white arrows). Scale bar: 100 µm. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)