. 2021 Mar 10;30(7):619–628. doi: 10.1093/hmg/ddab068

Table 3.

Association of lung function and MDD–PRS with COPD and MDD in European BioVU participants (2007–2019)

PRS	COPD				MDD
PRS	OR^a	95% CI^a	OR^b	95% CI^b	OR^a	95% CI^a	OR^b	95% CI^b
FEV₁	0.87	0.84–0.90	0.87	0.84–0.90	1.00	0.96–1.04	0.99	0.95–1.03
FVC	0.94	0.91–0.98	0.95	0.91–0.99	1.00	0.96–1.04	0.99	0.95–1.03
FEV₁/FVC	0.83	0.81–0.86	0.83	0.80–0.87	1.00	0.96–1.04	1.01	0.97–1.05
PEF	0.89	0.86–0.92	0.88	0.85–0.92	1.03	0.99–1.07	1.03	0.99–1.07
MDD	1.13	1.09–1.17	1.07	1.03–1.12	1.27	1.22–1.32	1.24	1.19–1.30

COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in one second; FVC, forced vital capacity; MDD, major depressive disorder; PEF, peak expiratory flow; OR, odds ratio; CI, confidence interval.

^aModel adjusted for age, sex and first three principal components (N = 72 445).

^bModel adjusted for age, sex, first three principal components and ever smoking (N = 53 503).