Table 2.
Characteristics of AD, DS and age matched control study population used to measure serum iron, ferritin, hepcidin, and IL-6.
| Characteristic | Controls N = 50 | AD N = 50 | DS N = 47 | Significant p-value |
|---|---|---|---|---|
| Males, n (%) 25 (50%) | 25 (50%) | 30 (60%) | 25 (53%) | |
| Females n (%) | 25 (50%) | 20 (4%) | 22 (47%) | |
| Age | 50 ± 27 | 72 ± 23 | 47 ± 22 | |
| Older controls | N = 50, 65± 20 | |||
| Iron parameters | ||||
| Serum iron (μmol/L) | 20.18 ± 5.1 | 15.4 ± 10.1 | 16.6 ± 9.9 | |
| Serum Ferritin (μg/L) | 212.67 ± 72.6 | 140.5 ± 231.1 | 133.82 ± 331.5 | <0.0001 |
| Serum Hepcidin (μg/L) | 25.35 ± 26.6 | 36.3 ± 51.2 | 188.32 ± 430.9 | <0.0001 |
| Serum IL-6 (pg/ml) | 66.23 ± 70.5 | 378.51 ± 201.89 | 304.03 ± 330 | <0.0001 |
Data are expressed as number of patients (percent), mean ± SD. Probability value (p) denote difference among control, AD and DS patient groups. One-way analysis of variance (ANOVA) was used to compare age between groups and statistical analysis was measured with Mann–Whitney U test.