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. 2021 Apr 30;11:649347. doi: 10.3389/fonc.2021.649347

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Copyright © 2021 Chang, Yuan and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction and validation of the ferroptosis-related genes prognostic signature in ccRCC patients. (A) Univariate Cox regression analysis showed that 27 ferroptosis-related genes were related to the overall survival rate (OS) of ccRCC patients. (B) Distribution of risk scores of high- and low-risk BCLA patients based on the ferroptosis-related genes prognostic signature. (C) The scatter plot showed the correlation between the survival status of high- and low-risk ccRCC patients. (D) The heat map showed the differences in the expression of 11 ferroptosis-related genes between high and low risk patients. (E) Kaplan–Meier survival curve showed that the survival time of the high-risk group was significantly shorter than that of the low-risk score group. (F) PCA showed that 11 ferroptosis-related genes were distributed differently between high-risk groups and low-risk groups. (G) ROC curve analysis of risk score as an independent prognostic factor.