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. 2021 Apr 24;12(12):3597–3610. doi: 10.7150/jca.55519

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CAR inhibited the PI3K/AKT signalling pathway. (A and B) The protein levels of PI3K, p-PI3K and its downstream effector molecule AKT, and p-AKT were examined by Western blot in EC9706 cells treated with different concentrations of CAR or DMSO, and β-actin served as the loading control. With increasing CAR concentrations, the protein levels of p-PI3K and p-AKT decreased significantly, while the expression levels of PI3K and AKT remained unchanged. The data are presented as the mean ± SD (n = 3, each group). *p < 0.05, **p < 0.01 vs the NC group.