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PKM2 acts on the STAT family in the differentiation of pro-inflammatory T cell subsets. PKM2 can regulate the phosphorylation of STAT3 to induce the differentiation of T cells into Th17 to participate in inflammation-related diseases; and then regulate STAT1/STAT4 to induce Th1 formation and partake in cellular immunity. The last, PKM2 can modulate STAT5 to combine with TGF-β, induce Treg formation and maintain immune tolerance.
