Table 3.
Joint-effect analysis of SOX4 and AFP for overall survival and recurrence-free survival
| Type | Group | SOX4 expression | APF expression | No. of event | MST (month) | Crude HR (95%CI) | Crude P value | Adjusted HR (95%CI) | Adjusted P value# |
|---|---|---|---|---|---|---|---|---|---|
| OS | 1 | Low | Low | 22/74 | 55.6 | Ref. | 0.001 | Ref. | 0.009 |
| 2 | Low | High | 24/71 | 51.0 | 1.238 (0.694-2.208) | 0.470 | 1.380 (0.718-2.651) | 0.333 | |
| High | Low | ||||||||
| 3 | High | High | 36/64 | 37.6 | 2.617 (1.537-4.455) | <0.001 | 4.667 (1.631-13.358) | 0.004 | |
| RFS | 1 | Low | Low | 36/74 | 45.5 | Ref. | 0.013 | Ref. | 0.163 |
| 2 | Low | High | 37/71 | 41.3 | 1.136 (0.718-1.797) | 0.587 | 0.960 (0.598-1.542) | 0.867 | |
| High | Low | ||||||||
| 3 | High | High | 43/64 | 31.4 | 1.861 (1.194-2.901) | 0.006 | 1.537 (0.964-2.452) | 0.071 |
Note: Group 1 stands for a combination of AFP low expression and SOX4 low expression; Group 2 stands for combinations of AFP low expression and SOX4 high expression, as well as AFP high expression and SOX4 low expression; Group 3 stand for a combination of AFP high expression and SOX4 high expression.