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. 2021 Apr 15;11(13):6240–6250. doi: 10.7150/thno.55953

Figure 6.

Figure 6

D2O-MRI guided neurointervention drug delivery to a brain tumor in a representative mouse. A) T2w image showing the location of the tumor (yellow arrow). Pre-D2O images, post-D2O images, contrast maps (∆SI = Spost- Spre), and maps of relative signal change (%) with D2O injected at 50 µL/min (B), 100 µL/min (C), 150 µL/min (D), and 200 µL/min (E), respectively. F) Bar plots showing the comparison between the mean MRI signal changes in tumor regions of three mice using two different flow rates (P = 0.0382, paired Student's t-test). G) ex vivo fluorescence imaging of IgG-FITC accumulated in the mouse brains with the IgG injected either by D2O-guided IA injection or by IV injection (P = 0.0023, unpaired Student's t-test).