Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 15;11(13):6251–6277. doi: 10.7150/thno.57689

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Molecular mechanisms involved in the regulation of thyroid-specific genes including sodium iodide symporter (NIS) in RAI-refractory differentiated thyroid cancer. (A) Notch signaling pathway. (B) TGF-ß/Smad signaling pathway. (C) Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. (D) Wnt/ß-catenin signaling pathway. Abbreviations: DNMT1: DNA methyltransferase 1; FoxP3: forkhead transcription factor 3; HIF1-ɑ: hypoxia-inducible factor-ɑ; IκB: Inhibitory κB; LRP5/6: low-density lipoprotein receptor-related protein 5/6; NECD: notch extracellular domain; NICD: notch intracellular domain; NOX4: NADPH oxidase 4; P: phosphorylation; ROS: reactive oxygen species; Ub: ubiquitination. Images were created with BioRender.com.