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Schematic diagram of factors related to NIS membrane targeting in RAI-refractory differentiated thyroid cancer. Abbreviations: ARF4: ADP-ribosylation factor 4; ERAD: endoplasmic-reticulum-associated protein degradation; LARG: leukemia-associated RhoA guanine exchange factor; PBF: pituitary tumor-transforming gene 1 (PTTG1)-binding factor; PIGU: phosphatidylinositol glycan anchor biosynthesis class U; VCP: valosin-containing protein. Image was created with BioRender.com.
