Figure 3.

Left Panel: Schematic of Biotin-Bevacizumab injection followed by an avidin chase. Middle Panel: [¹¹¹In]In-DTPA-Bv and [¹¹¹In]In-DTPA-Bt-Bv were utilized to examine the biodistribution profiles of the tracer 27 h post injection. [¹¹¹In]In-DTPA-Bt-Bv exhibited significantly lower blood uptake and higher liver uptake. Left Panel: In the therapeutic study, the [⁹⁰Y]Y-DTPA-Bt-Bv cohort of mice was significantly inhibited compared to the [⁹⁰Y]Y-DTPA-Bv. Adapted with permission from Yudistiro et al., Molecular Pharmaceutics, 2018. Copyright 2018 American Chemical Society.