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. 2021 Apr 26;11(13):6542–6559. doi: 10.7150/thno.54589

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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PET images (representative axial slices) obtained in AD and WT animals after intravenous administration of [¹¹C]4 at different ages. Images have been generated by dividing, voxel-by-voxel, averaged images obtained at 6, 8, 10, and 12 months of age by averaged images obtained at 4 months of age. VOIs corresponding to the cortex, hippocampus, striatum, brain stem, thalamus and cerebellum are drawn for anatomical reference.