Figure 2.

A novel bioreactor enables stretch conditioning under enhanced biomimetic conditions. (A) Schematic illustration of mechanical fixation of the primary EHT in a biomimetic culture chamber (BMCC). Red arrows indicate the stretching direction. (B) Setup of the BMCC system. A micro-controller (left dashed box) collects contraction data, generates stimulation pulses, and controls rocking of the BMCC platform by a stepper motor (right dashed box). (C) Computer interface of BMCC system. Data storage and stimulation parameters are set on a control panel (left). Tissue forces are displayed at arbitrary time scales in freely assignable oscilloscope windows (middle and right panels). Each peak represents one contraction.