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. 2021 Apr 19;11(13):6334–6354. doi: 10.7150/thno.59342

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(A) The formation and light-triggered decomposition of versatile polymeric nanoparticles co-delivering anticancer therapeutic DOX and APA. (B) Schematic illustration of the mechanism of the reversal of cancer MDR via ACP-Dox+Apa nanoparticles. (C) The tumor tissue images of the MCF-7/ADR tumor-bearing nude mice. (D) Tumor growth profiles. (E) H&E, Ki67 and TUNEL analyses of tumor tissues from MCF-7/ADR xenografts-bearing nude mice. Reproduced with permission from Ref. 55, Copyright © 2018, American Chemical Society. Abbreviations: APA: apatinib; PpIX: protoporphyrin IX; ROS: reactive oxygen; PDT: photodynamic therapy; H&E: hematoxylin and eosin; TUNEL: terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling.