Table 1.

Clinically approved or under clinical trial nanomedicines

Product	Drug	Carrier components	Company	Stage	Ref.
Nab-Paclitaxel (Abraxane)	PTX	Human serum albumin	Abraxis BioScience	FDA and EMA approved	9
Genexol-PM	PTX	Micelle: mPEG-PDLLA	Samyang Biopharm	Approved in Korea	10
Apealea	PTX	Micelle: two isoforms of N-retinoyl-L-cysteic acid Methyl ester sodium salt	Oasmia Pharmaceutical	EMA approved	11
Lipusu	PTX	Liposome: lecithin/cholesterol	Nanjing Luye Sike Pharmaceutical Co.	Phase IV	12
Doxil	DOX	Liposome: HSPC, cholesterol, mPEG-DSPE	Johnson &Johnson	FDA and EMA approved	13
Myocet	DOX	Liposome: phosphatidylcholine, cholesterol	Teva	EMA approved	14
ThermoDox	DOX	Thermosensitive liposomal doxorubicin	MedKoo Biosciences Inc.	Phase III completed	15
Nanoparticle generator	DOX	Porous silicon microparticle with polymeric doxorubicin	/	Planning of phase I	16
NC-6004	Cisplatin	Micelle: PEG-P(Glu)	Nano Carrier Co.	Phase I/II	17
Lipoplatin	Cisplatin	Liposome: SPC/cholesterol/DPPG/mPEGDSPE	Regulon Inc.	Phase II/III	18
CRLX101	CPT	PEG-modified β-cyclodextrin	Cerulean Pharma Inc.	Phase II	19
NKTR-102	Irinotecan	PEG (four-arm) conjugation	Nektar Therapeutics	Phase II	20
Onivyde	Irinotecan	Liposome: DSPC, cholesterol, mPEG-DSPE	Merrimack Pharmaceuticals	Phase II/III	21
DOTAP: Chol-TUSC2	TUSC2	DOTAP: Chol	Genprex, Inc.	Phase I/II	22
Mepact	Mifamurtide	Liposome: POPC,OOPS	Takeda Pharmaceutical	EMA approved	23
Marqibo	Vincristine sulfate	Liposome: sphingomyelin, cholesterol	Talon Therapeutics	FDA approved	24
Vyxeos	Cytarabine and daunorubicin	Liposome: DSPC,DSPG, cholesterol	Jazz Pharmaceuticals	FDA and EMA approved	25