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. 2021 Apr 30;11:664927. doi: 10.3389/fonc.2021.664927

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Copyright © 2021 Zhao, Guo, Cheng, Liao, Bi, Gong, Zhang, Guo, Wang, Yu, Jin, Tan and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of RIPK3 aggravates tumor burden in Apc^Min/+ mice. (A) Polyps in representative intestines from Apc^min/+ and Apc^min/+Ripk3^-/- mice. (B, C) Number of polyps formed (B) and tumor load (C) in 16-week-old Apc^min/+ and Apc^min/+Ripk3^-/- intestines. (D) Distribution of tumor size in 16-week-old Apc^min/+ and Apc^min/+Ripk3^-/- mice. (E) Images of the H&E-stained intestines from Apc^min/+ and Apc^min/+Ripk3^-/- mice. (F, G) Hematocrit (F) and thymus weight (G) of 16-week-old WT, Ripk3^-/-, Apc^min/+ and Apc^min/+Ripk3^-/- mice. (H) Survival of Apc^min/+ and Apc^min/+Ripk3^-/- mice as indicated. *p < 0.05, **p < 0.01 and ***p < 0.001 versus Apc^min/+ mice. (I, J) Whole intestines and colonic crypts were isolated from 16-week-old Apc^min/+ and Apc^min/+Ripk3^-/- mice. PCNA and cleavage of caspase-3 were analyzed by western blotting. *p < 0.05 and ***p < 0.001 versus Apc^min/+ mice.