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. 2021 Apr 30;11:664927. doi: 10.3389/fonc.2021.664927

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Copyright © 2021 Zhao, Guo, Cheng, Liao, Bi, Gong, Zhang, Guo, Wang, Yu, Jin, Tan and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of RIPK3 activates STAT3 signals in Apc^min/+ mice. (A) The expression of pSTAT3 in 6-week-old Apc^min/+ and Apc^min/+Ripk3^-/- intestinal tumors. (B) The levels of pSTAT3 in Apc^min/+ and Apc^min/+Ripk3^-/- colonic crypts. (C) Quantitative mRNA expression of IL-6 in Apc^min/+ and Apc^min/+Ripk3^-/- intestinal tumors. (D) The protein levels of IL-6 in Apc^min/+ and Apc^min/+Ripk3^-/- intestinal tumors as determined by ELISA. (E) The expression of STAT3 target genes in Apc^min/+ and Apc^min/+Ripk3^-/- intestinal tumors. (F) The expression of STAT3 target genes in Apc^min/+ and Apc^min/+Ripk3^-/- colonic crypts. (G, H) Quantitative mRNA expression of STAT3 target genes in Apc^min/+ and Apc^min/+Ripk3^-/- intestinal tumors and colonic crypts. *p < 0.05, **p < 0.01, ***p < 0.001 versus Apc^min/+ mice.