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. 2021 Apr 30;11:664927. doi: 10.3389/fonc.2021.664927

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Copyright © 2021 Zhao, Guo, Cheng, Liao, Bi, Gong, Zhang, Guo, Wang, Yu, Jin, Tan and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of IL-6 blocks tumor burden in Apc^min/+Ripk3^-/- mice. (A) Scheme for anti-IL6R antibody treatment in Apc^min/+Ripk3^-/- mice. (B) Four-week-old Apc^min/+Ripk3^-/- mice were injected with anti-IL6R antibody with at a dosage of 4 mg/kg weekly for 10 weeks. The clinical scores were monitored. (C) Numbers of intestinal tumors in Un- or anti-IL6R-treated Apc^min/+Ripk3^-/- mice. (D, E) Hematocrit (D) and thymus weight (E) of Apc^min/+Ripk3^-/- mice after anti-IL6R therapy for 10 weeks. (F) Intestinal tumors were collected from PBS and anti-IL6R-treated Apc^min/+Ripk3^-/- mice. The levels of p-STAT3 were determined by western blotting. (G, H) The expression of STAT3 target genes expression in PBS and anti-IL6R-treated Apc^min/+Ripk3^-/- intestinal tumors. *p < 0.05, ***p < 0.001 versus Un-treated Apc^min/+Ripk3^-/- mice.