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. 2021 Apr 30;11:649815. doi: 10.3389/fcimb.2021.649815

Figure 1.

Figure 1

Cervical tumors are enriched in estradiol (E2) and express estrogen receptor α. (A) (i) Concentrations of 17β-estradiol as determined by ELISA in blood plasma from healthy donors (Pl HD) or patients with CxCa (Pl CxCa) as well as in (ii) tissue samples of cervical tumors (CxCa), areas adjacent to the tumors (CxCa adj), and healthy cervices (Normal Cx). Graph shows mean values ± SEM of n = 30 per group. (B) Staining distribution of 17β-estradiol, estrogen receptor α, and aromatase in a representative tissue section of SCC cervix. Upper left image (i) shows haematoxylin and eosin staining of a tumour section; upper right image (ii) shows estradiol (E2) staining which was predominantly cytoplasmic in the tumor and both nuclear and cytoplasmic in the stroma and infiltrating cells; lower left image (iii) shows the nuclear staining of ERα in the stromal cells only; lower right image (iv) shows aromatase expression detected in the cytoplasm of the tumor, stroma and infiltrating cells. Inset: normal rabbit serum negative control. Symbol T indicates tumor location in each picture; * indicates stroma. Images are representative of n = 30. (reproduced from: Adurthi et al, Sci Rep. 2017 Dec 11;7(1):17289. doi: 10.1038/s41598-017- 17102-w. https://pubmed.ncbi.nlm.nih.gov/29229929/#&gid=article-figures&pid=figure-1-uid-0). **P < 0.01, ***P < 0.001.