TABLE 1.
Summary of S protein of PEDV published in NCBI and UniProt.
| GeneBank/UniProtKB | S* (aa) | Homology (%) vs. CV777 | S1 | S2 | Fusion peptide | Coiled coil | TM | Motif (KxHxx) | Interaction with host receptor (ANPEP) and note |
|---|---|---|---|---|---|---|---|---|---|
| UniRule: UR000865645 | 16–1,173 | 16–536 | 537–1,173 | 753–773 | 1,063–1,105 834–878 | 1,169–1,173 | 417–547 | ||
| Belongs to the alphacoronaviruses spike protein family. The KxHxx motif seems to function as an ER retrieval signal. In contrast to sergoroups 2 and 3, glycoprotein from seogroup 1 is not cleaved into S and S2. Homotrimer. During virus morpphogenesis, found in a complex with M and HE proteins. Interacts with host ANPEP. Note: Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. | |||||||||
| AAK38656.1 | 1,383 | - | 231–733 | 741–1,344 | CV77, Pensaert and De Bouck (1978) | ||||
| A0A5B8YRH6 | 1,386 | 9.2% identity (97.0% similar) | 234–736 | 744–1,385 | 958–978 | 1,039–1,083 1,275–1,317 | 1,328–1,347 | 1,382–1,386 | 100% identity to AAk3865631 in Uniprot Blast |
| AAM19716.1 | 1,386 | 92.5% identity (97.0% similar) | 234–736 | 744–1,347 | Korean isolate; Kang et al. (2005) | ||||
| Q8QQ98 | 1,386 | 92.5% identity (97.0% similar) | 234–736 | 744–1,385 | 958–978 | 1,039–1,083 1,275–1,317 | 1,328–1,347 | 1,382–1,386 | 100% identity to AAM19716.1 in Uniprot Blast |
| AGN293201 | 1,382 | 95.9% identity (98.4% similar) | 230–732 | 740–1,343 | a new Porcineepidemic diarrhea virus isolated of China; Chen et al. (2012) | ||||
| R9TI84 | 1,382 | 95.9% identity (98.4% similar) | 230–732 | 740–1,381 | 954–974 | 1,035–1,079 1,271–1,313 | 1,324–1,343 | 1,378–1,382 | 100% identity to AGN29320.1 in Uniprot Blast |
| AST13221.1 | 1,380 | 97.8% identity (99.3% similar) | 235–737 | 745–1,348 | 85–7 mutant strain 1; Sun et al. (2017) | ||||
| A0A288Y8U4 | 1,380 | 98.1% identity (99.3% similar) | 235–737 | 745–1,378 | 959–979 | 1,040–1,084 1,276–1,318 | 1,329–1,348 | 100% identity to AST13221.1 in Uniprot Blast | |
| ASU09581.1 | 1,386 | 91.9% identity (96.6% similar) | 234–736 | 744–1,347 | HUA–PED96 Vietnam; Do Hai et al. (2016) | ||||
| A0AU2UB55 | 1,386 | 91.9% identity (96.6% similar) | 234–736 | 744–1,385 | 958–978 | 1,039–1,083 1,275–1,317 | 1,328–1,347 | 1,382–1,386 | 100% identity to ASU09581.1 Uniprot Blast |
| MK841495 (QED40665.1) | 1,386 | 92.7% identity (97.0% similar) | PEDV YZ, China; Wang et.al. (2019) | ||||||
| A0A5B8YRH6 | 1,386 | 92.7% identity (97.0% similar) | 234–736 | 744–1,385 | 958–978 | 1,039–1,083 1,275–1,317 | 1,328–1,347 | 1,382–1,386 | 100% identity to MK841495 in Uniprot Blast |
*
Spike (S) protein consists with two domains (S1 and S2) with transmembrane (TM). The residues corresponding to each protein positions were represented in the table. Homology (%) is compared to corona-like agent (CV777) as the causative pathogan, which was partially fulfilled Koch’s postulates and described by Belgium scientists at the Ghent University in 1978. The Annotation and conditions in the UniRule (UR000865645) are derived from the following entries; P15423 (SPIKE_CVH22).