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. 2021 Apr 15;11:628624. doi: 10.3389/fonc.2021.628624

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Copyright © 2021 Zhao, Tian and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overexpression of circATP2B1 reversed miR-326-3p/miR-330-5p-induced inhibitory effects on PKM2 protein abundance. (A) PKM2 expression in GT, HDAC and PDAC with immunohistochemistry staining. (B, C) The predicted miR-326-3p/miR-330-5p binding sites in the 3’-UTR region of PKM2 (PKM2-3’UTR-Wt) and the designed mutant sequence (PKM2-3’UTR-Mut) were indicated. (F) Luciferase assay of miR-326-3p/miR-330-5p and PKM2 was conducted. Relative luciferase activities for PKM2-3’UTR-Wt and PKM2-3’UTR-Mut group. (D–F). PKM2 expression change according to circATP2B1 abundance. (G–J). Silencing of circATP2B1 partly reversed miR-326-3p(−)/miR-330-5p(−)-induced elevation on PKM2. Data were presented as the mean ± SD. (*P <0.05, **P <0.01).