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Molecular interactions between crocetin or crocin with VEGFR2. Three-dimensional view of crocetin and crocin located in the binding site of VEGFR2 are shown in (A) and (B), with affinities of −8.6 and −8.4 kcal/mol, respectively. Hydrophobic interactions (dashed lines), hydrogen bonds (blue lines) and important residues of the binding site are shown.
