FIGURE 4.

XBJ regulates the activities of GSK-3β, NF-κB and CREB in the liver of CLP-induced ALI mice (A) Representative immunoblots of GSK-3β, NF-κB and CREB protein expression in liver lysates. (B-D) Administration of XBJ increased GSK-3β and CREB activity, while NF-κB activity was reduced in vivo. Con: control group that underwent sham surgery; CLP: model group with CLP surgery; L-XBJ: group with CLP surgery + XBJ low dose group (4 ml/kg/day); H-XBJ: group with CLP surgery + XBJ high dose group (8 ml/kg/day); DXM: group with CLP surgery + Dexamethasone (5 mg/kg/day). Compared with the control group, #p < 0.05, ##p < 0.01 were considered to be significant; Compared with the CLP group, *p < 0.05, **p < 0.01 were considered to be significant. Data are expressed as mean ± SD.