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. 2021 Apr 30;12:686116. doi: 10.3389/fgene.2021.686116

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Copyright © 2021 Yang, Sun, Cao, Li, Zhang, Li, Zhao, Zhan, Zang, Li, Zhang, Liu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circRNA expression profiles of AMI patients (Group T: T1, T2, T3, T4, and n = 4) and mild coronary artery stenosis patients (Group C: C1, C2, C3, C4, and n = 4) screened by microarray analysis. (A) Heat Map showing a distinguishable expression profile of circRNAs between two groups. Black stands for 0, indicating no change in gene expression; red represents up-regulation, and green represents down-regulation. (B) Boxplot view showed the distribution of normalized expression intensity values for two groups. (C) Scatter plot indicated the variation of circRNA expression in AMI patients (y-axis) and mild coronary artery stenosis patients (x-axis). (D) Volcano plots visualizing differential circRNA expression between the two groups. The vertical lines correspond to a 2.0-fold change (FC) (log2 scaled) (up-regulation and down-regulation, respectively).